Symbol: Name: ID: |
SKP2 S-phase kinase-associated protein 2 (p45) GFS:810 |
Gene name: | SKP2 |
Chromosome: | 5p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FBXL1, FBL1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1351663 | Rat Genome Database ID: | RGD:1562456 |
HGNC ID: | HGNC:10901 | RefSeq IDs: | NM_005983 |
Entrez Gene ID: | 6502 | Ensembl Gene ID: | ENSG00000145604 |
VEGA IDs: | OTTHUMG00000131106 | UniProt ID: | Q13309 |
UCSC ID: | uc003jkc.1 | OMIM ID: | 601436 |
Pubmed: | PMID8646875 | ||
CCDS IDs: | CCDSCCDS3915.1 CCDS CCDS3916.1 |
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms. [provided by RefSeq].
Products for SKP2 gene
Catalog | Product Name | Application | Company |
GFS:E00810 | S-phase kinase-associated protein 2 (p45); ELISA kit | ELISA | n/a |
GFS:A00810 | S-phase kinase-associated protein 2 (p45); Anti | ANTIBODIES | n/a |
GFS:P00810 | S-phase kinase-associated protein 2 (p45); Protien | Protien | n/a |