Symbol: Name: ID: |
SKP1 S-phase kinase-associated protein 1 GFS:806 |
Gene name: | SKP1 |
Chromosome: | 5q31 |
Previous Symbols: | SKP1A |
Previous Names: | S-phase kinase-associated protein 1A (p19A) |
Aliases: | EMC19, OCP2, TCEB1L, MGC34403, OCP-II, p19A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103575 | Rat Genome Database ID: | RGD:1359648 |
HGNC ID: | HGNC:10899 | RefSeq IDs: | NM_006930 |
Entrez Gene ID: | 6500 | Ensembl Gene ID: | ENSG00000113558 |
VEGA IDs: | OTTHUMG00000129117 | UniProt ID: | P63208 |
UCSC ID: | uc003kzc.3 | OMIM ID: | 601434 |
Pubmed: | PMID7553852 PMID 8646875 | ||
CCDS IDs: | CCDSCCDS4171.1 CCDS CCDS4172.1 |
S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene. This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq].
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.
Products for SKP1 gene
Catalog | Product Name | Application | Company |
GFS:E00806 | S-phase kinase-associated protein 1; ELISA kit | ELISA | n/a |
GFS:A00806 | S-phase kinase-associated protein 1; Anti | ANTIBODIES | n/a |
GFS:P00806 | S-phase kinase-associated protein 1; Protien | Protien | n/a |