| Symbol: Name: ID: |
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 GFS:5950 |
| Gene name: | RAPGEF5 |
| Chromosome: | 7p15.3 |
| Previous Symbols: | |
| Previous Names: | |
| Aliases: | KIAA0277, GFR, MR-GEF |
| Name Aliases: | M-Ras-regulated GEF |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:2444365 | Rat Genome Database ID: | RGD:1561668 |
| HGNC ID: | HGNC:16862 | RefSeq IDs: | NM_012294 |
| Entrez Gene ID: | 9771 | Ensembl Gene ID: | ENSG00000136237 |
| VEGA IDs: | OTTHUMG00000152525 | UniProt ID: | Q92565 |
| UCSC ID: | uc003svg.2 | OMIM ID: | 609527 |
| Pubmed: | PMID9039502 PMID 10486569 | ||
| CCDS IDs: | |||
Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008].
Function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.
Products for RAPGEF5 gene
| Catalog | Product Name | Application | Company |
| GFS:E05950 | Rap guanine nucleotide exchange factor (GEF) 5; ELISA kit | ELISA | n/a |
| GFS:A05950 | Rap guanine nucleotide exchange factor (GEF) 5; Anti | ANTIBODIES | n/a |
| GFS:P05950 | Rap guanine nucleotide exchange factor (GEF) 5; Protien | Protien | n/a |
