| Symbol: Name: ID: |
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 GFS:5941 |
| Gene name: | RAPGEF2 |
| Chromosome: | 4q32.1 |
| Previous Symbols: | PDZGEF1 |
| Previous Names: | PDZ domain containing guanine nucleotide exchange factor (GEF) 1 |
| Aliases: | PDZ-GEF1, RA-GEF, DKFZP586O1422, KIAA0313 |
| Name Aliases: | Rap GEP |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:2659071 | Rat Genome Database ID: | RGD:1306434 |
| HGNC ID: | HGNC:16854 | RefSeq IDs: | NM_014247 |
| Entrez Gene ID: | 9693 | Ensembl Gene ID: | ENSG00000109756 |
| VEGA IDs: | UniProt ID: | Q9Y4G8 | |
| UCSC ID: | uc003iqg.3 | OMIM ID: | 609530 |
| Pubmed: | PMID9205841 PMID 10934204 | ||
| CCDS IDs: | CCDSCCDS43277.1 | ||
Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008].
Function: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP.
Products for RAPGEF2 gene
| Catalog | Product Name | Application | Company |
| GFS:E05941 | Rap guanine nucleotide exchange factor (GEF) 2; ELISA kit | ELISA | n/a |
| GFS:A05941 | Rap guanine nucleotide exchange factor (GEF) 2; Anti | ANTIBODIES | n/a |
| GFS:P05941 | Rap guanine nucleotide exchange factor (GEF) 2; Protien | Protien | n/a |
