Symbol: Name: ID: |
RN7SK RNA, 7SK small nuclear GFS:34 |
Gene name: | RN7SK |
Chromosome: | 6p12.1 |
Previous Symbols: | |
Previous Names: | RNA, 7SK, nuclear |
Aliases: | 7SK |
Name Aliases: | |
Locus Type: | RNA, small nuclear |
Mouse Genome Database ID: | MGI:103186 | Rat Genome Database ID: | |
HGNC ID: | HGNC:10037 | RefSeq IDs: | NR_001445 |
Entrez Gene ID: | 125050 | Ensembl Gene ID: | ENSG00000202198 |
VEGA IDs: | UniProt ID: | ||
UCSC ID: | OMIM ID: | 606515 | |
Pubmed: | PMID8139910 PMID 1646389 | ||
CCDS IDs: |
7SK, also known as RN7SK, was discovered as an abundant small nuclear RNA gene found in metazoans in the mid-70s but a possible function has only recently been suggested.
Two independent studies have found that 7SK RNA binds the CDK9/cyclin T complex (known as elongation factor P-TEFb). P-TEFb activates transcription by phosphorylating the C-terminal domain of RNA polymerase II. This process is negatively regulated by the 7SK RNP.
The secondary structure of 7SK RNA shown here was proposed by Wassarman and Steitz on the basis of chemical modification and enzymatic cleavage experiments. This family contains a number of pseudogenes and 7SK derived repeats.
Gene Wiki entry for RN7SK
Products for RN7SK gene
Catalog | Product Name | Application | Company |
GFS:E00034 | RNA, 7SK small nuclear; ELISA kit | ELISA | n/a |
GFS:A00034 | RNA, 7SK small nuclear; Anti | ANTIBODIES | n/a |
GFS:P00034 | RNA, 7SK small nuclear; Protien | Protien | n/a |