Symbol: Name: ID: |
RASGRP4 RAS guanyl releasing protein 4 GFS:7771 |
Gene name: | RASGRP4 |
Chromosome: | 19q13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2386851 | Rat Genome Database ID: | RGD:620476 |
HGNC ID: | HGNC:18958 | RefSeq IDs: | NM_001146202 |
Entrez Gene ID: | 115727 | Ensembl Gene ID: | ENSG00000171777 |
VEGA IDs: | UniProt ID: | Q8TDF6 | |
UCSC ID: | uc002oir.2 | OMIM ID: | 607320 |
Pubmed: | PMID11956218 | ||
CCDS IDs: | CCDSCCDS46068.1 |
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009].
Function: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
Products for RASGRP4 gene
Catalog | Product Name | Application | Company |
GFS:E07771 | RAS guanyl releasing protein 4; ELISA kit | ELISA | n/a |
GFS:A07771 | RAS guanyl releasing protein 4; Anti | ANTIBODIES | n/a |
GFS:P07771 | RAS guanyl releasing protein 4; Protien | Protien | n/a |