Symbol: Name: ID: |
PDLIM5 PDZ and LIM domain 5 GFS:6507 |
Gene name: | PDLIM5 |
Chromosome: | 4q22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | LIM, Enh |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927489 | Rat Genome Database ID: | RGD:621076 |
HGNC ID: | HGNC:17468 | RefSeq IDs: | NM_001011513 |
Entrez Gene ID: | 10611 | Ensembl Gene ID: | ENSG00000163110 |
VEGA IDs: | OTTHUMG00000130973 | UniProt ID: | Q96HC4 |
UCSC ID: | uc003hti.2 | OMIM ID: | 605904 |
Pubmed: | PMID15346770 | ||
CCDS IDs: | CCDSCCDS3641.1 CCDS CCDS47102.1 CCDS CCDS47103.1 CCDS CCDS47104.1 |
PDZ and LIM domain protein 5 is a protein that in humans is encoded by the PDLIM5 gene.
The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized. [provided by RefSeq, Jul 2008].
Function: May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).
Products for PDLIM5 gene
Catalog | Product Name | Application | Company |
GFS:E06507 | PDZ and LIM domain 5; ELISA kit | ELISA | n/a |
GFS:A06507 | PDZ and LIM domain 5; Anti | ANTIBODIES | n/a |
GFS:P06507 | PDZ and LIM domain 5; Protien | Protien | n/a |