Symbol: Name: ID: |
NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) GFS:5995 |
Gene name: | NDC80 |
Chromosome: | 18p11.31 |
Previous Symbols: | KNTC2 |
Previous Names: | highly expressed in cancer, rich in leucine heptad repeats (yeast), "kinetochore associated 2" |
Aliases: | HEC, HEC1, hsNDC80, TID3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914302 | Rat Genome Database ID: | RGD:1310154 |
HGNC ID: | HGNC:16909 | RefSeq IDs: | NM_006101 |
Entrez Gene ID: | 10403 | Ensembl Gene ID: | ENSG00000080986 |
VEGA IDs: | OTTHUMG00000131483 | UniProt ID: | O14777 |
UCSC ID: | uc002kli.2 | OMIM ID: | 607272 |
Pubmed: | PMID9315664 PMID 12351790 | ||
CCDS IDs: | CCDSCCDS11827.1 |
Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
Products for NDC80 gene
Catalog | Product Name | Application | Company |
GFS:E05995 | NDC80 homolog, kinetochore complex component (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A05995 | NDC80 homolog, kinetochore complex component (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P05995 | NDC80 homolog, kinetochore complex component (S. cerevisiae); Protien | Protien | n/a |