Symbol: Name: ID: |
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) GFS:5866 |
Gene name: | NPL |
Chromosome: | 1q25 |
Previous Symbols: | C1orf13 |
Previous Names: | chromosome 1 open reading frame 13 |
Aliases: | NPL1, DHDPS1 |
Name Aliases: | dihydrodipicolinate synthetase homolog 1 (E. coli) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1921341 | Rat Genome Database ID: | RGD:1549702 |
HGNC ID: | HGNC:16781 | RefSeq IDs: | NM_001200050 |
Entrez Gene ID: | 80896 | Ensembl Gene ID: | ENSG00000135838 |
VEGA IDs: | OTTHUMG00000035321 | UniProt ID: | Q9BXD5 |
UCSC ID: | uc001gpq.1 | OMIM ID: | 611412 |
Pubmed: | PMID11318611 | ||
CCDS IDs: | CCDSCCDS1350.1 |
This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Function: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface (By similarity).
Products for NPL gene
Catalog | Product Name | Application | Company |
GFS:E05866 | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase); ELISA kit | ELISA | n/a |
GFS:A05866 | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase); Anti | ANTIBODIES | n/a |
GFS:P05866 | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase); Protien | Protien | n/a |