Symbol: Name: ID: |
MXD4 MAX dimerization protein 4 GFS:3350 |
Gene name: | MXD4 |
Chromosome: | 4p16.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MAD4, MSTP149, MST149, bHLHc12 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104991 | Rat Genome Database ID: | RGD:1305093 |
HGNC ID: | HGNC:13906 | RefSeq IDs: | NM_006454 |
Entrez Gene ID: | 10608 | Ensembl Gene ID: | ENSG00000123933 |
VEGA IDs: | OTTHUMG00000090243 | UniProt ID: | Q14582 |
UCSC ID: | uc003geu.1 | OMIM ID: | |
Pubmed: | PMID8521822 | ||
CCDS IDs: | CCDSCCDS3361.1 |
Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008].
Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).
Products for MXD4 gene
Catalog | Product Name | Application | Company |
GFS:E03350 | MAX dimerization protein 4; ELISA kit | ELISA | n/a |
GFS:A03350 | MAX dimerization protein 4; Anti | ANTIBODIES | n/a |
GFS:P03350 | MAX dimerization protein 4; Protien | Protien | n/a |