Symbol: Name: ID: |
MXD3 MAX dimerization protein 3 GFS:3443 |
Gene name: | MXD3 |
Chromosome: | 5q35.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MAD3, bHLHc13 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104987 | Rat Genome Database ID: | RGD:628624 |
HGNC ID: | HGNC:14008 | RefSeq IDs: | NM_001142935 |
Entrez Gene ID: | 83463 | Ensembl Gene ID: | ENSG00000213347 |
VEGA IDs: | OTTHUMG00000130854 | UniProt ID: | Q9BW11 |
UCSC ID: | uc003mgb.2 | OMIM ID: | 609450 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS4416.1 CCDS CCDS47347.1 |
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008].
Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).
Products for MXD3 gene
Catalog | Product Name | Application | Company |
GFS:E03443 | MAX dimerization protein 3; ELISA kit | ELISA | n/a |
GFS:A03443 | MAX dimerization protein 3; Anti | ANTIBODIES | n/a |
GFS:P03443 | MAX dimerization protein 3; Protien | Protien | n/a |