Symbol: Name: ID: |
DERL3 Der1-like domain family, member 3 GFS:3602 |
Gene name: | DERL3 |
Chromosome: | 22q11.23 |
Previous Symbols: | C22orf14 |
Previous Names: | chromosome 22 open reading frame 14 |
Aliases: | FLJ43842, MGC71803, derlin-3, IZP6 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917627 | Rat Genome Database ID: | RGD:1597373 |
HGNC ID: | HGNC:14236 | RefSeq IDs: | NM_001002862 |
Entrez Gene ID: | 91319 | Ensembl Gene ID: | ENSG00000099958 |
VEGA IDs: | OTTHUMG00000150743 | UniProt ID: | Q96Q80 |
UCSC ID: | uc002zyk.3 | OMIM ID: | 610305 |
Pubmed: | PMID15215855 | ||
CCDS IDs: | CCDSCCDS33615.1 CCDS CCDS42986.1 CCDS CCDS46672.1 |
Derlin-3 is a protein that in humans is encoded by the DERL3 gene.
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008].
Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.
Products for DERL3 gene
Catalog | Product Name | Application | Company |
GFS:E03602 | Der1-like domain family, member 3; ELISA kit | ELISA | n/a |
GFS:A03602 | Der1-like domain family, member 3; Anti | ANTIBODIES | n/a |
GFS:P03602 | Der1-like domain family, member 3; Protien | Protien | n/a |