Symbol: Name: ID: |
DERL2 Der1-like domain family, member 2 GFS:6842 |
Gene name: | DERL2 |
Chromosome: | 17p13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | F-LAN-1, FLANa, F-LANa, CGI-101, derlin-2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2151483 | Rat Genome Database ID: | RGD:1593332 |
HGNC ID: | HGNC:17943 | RefSeq IDs: | NM_016041 |
Entrez Gene ID: | 51009 | Ensembl Gene ID: | ENSG00000072849 |
VEGA IDs: | OTTHUMG00000102040 | UniProt ID: | Q9GZP9 |
UCSC ID: | uc002gcc.1 | OMIM ID: | 610304 |
Pubmed: | PMID10810093 PMID 11500051 | ||
CCDS IDs: | CCDSCCDS11073.1 |
Derlin-2 is a protein that in humans is encoded by the DERL2 gene.
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]. Sequence Note: removed 1 base from the 5' end that did not align to the reference genome assembly.
Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
Products for DERL2 gene
Catalog | Product Name | Application | Company |
GFS:E06842 | Der1-like domain family, member 2; ELISA kit | ELISA | n/a |
GFS:A06842 | Der1-like domain family, member 2; Anti | ANTIBODIES | n/a |
GFS:P06842 | Der1-like domain family, member 2; Protien | Protien | n/a |