Symbol: Name: ID: |
DBF4B DBF4 homolog B (S. cerevisiae) GFS:6784 |
Gene name: | DBF4B |
Chromosome: | 17q21.31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ13087, DRF1, ASKL1, chifb, ZDBF1B |
Name Aliases: | chiffon homolog B (Drosophila), |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:17883 | RefSeq IDs: | NM_025104 |
Entrez Gene ID: | 80174 | Ensembl Gene ID: | ENSG00000161692 |
VEGA IDs: | UniProt ID: | Q8NFT6 | |
UCSC ID: | uc002ihf.2 | OMIM ID: | 611661 |
Pubmed: | PMID15668232 | ||
CCDS IDs: | CCDSCCDS11485.1 CCDS CCDS45706.1 |
This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].
Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.
Products for DBF4B gene
Catalog | Product Name | Application | Company |
GFS:E06784 | DBF4 homolog B (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A06784 | DBF4 homolog B (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P06784 | DBF4 homolog B (S. cerevisiae); Protien | Protien | n/a |