Symbol: Name: ID: |
CADPS Ca++-dependent secretion activator GFS:3625 |
Gene name: | CADPS |
Chromosome: | 3p21.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CAPS, KIAA1121, CAPS1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1350922 | Rat Genome Database ID: | RGD:708573 |
HGNC ID: | HGNC:1426 | RefSeq IDs: | NM_003716 |
Entrez Gene ID: | 8618 | Ensembl Gene ID: | ENSG00000163618 |
VEGA IDs: | OTTHUMG00000158651 | UniProt ID: | Q9ULU8 |
UCSC ID: | uc003dll.2 | OMIM ID: | 604667 |
Pubmed: | PMID1516133 | ||
CCDS IDs: | CCDSCCDS2898.1 CCDS CCDS2899.1 CCDS CCDS46858.1 |
Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008].
Function: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).
Products for CADPS gene
Catalog | Product Name | Application | Company |
GFS:E03625 | Ca++-dependent secretion activator; ELISA kit | ELISA | n/a |
GFS:A03625 | Ca++-dependent secretion activator; Anti | ANTIBODIES | n/a |
GFS:P03625 | Ca++-dependent secretion activator; Protien | Protien | n/a |