Symbol: Name: ID: |
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 GFS:6170 |
Gene name: | CTDSP2 |
Chromosome: | 12q14.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | OS4, SCP2, PSR2 |
Name Aliases: | conserved gene amplified in osteosarcoma, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1098748 | Rat Genome Database ID: | |
HGNC ID: | HGNC:17077 | RefSeq IDs: | NM_005730 |
Entrez Gene ID: | 10106 | Ensembl Gene ID: | ENSG00000175215 |
VEGA IDs: | UniProt ID: | O14595 | |
UCSC ID: | uc001sqm.2 | OMIM ID: | 608711 |
Pubmed: | PMID9315096 PMID 12721286 | ||
CCDS IDs: | CCDSCCDS41801.1 |
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 is an enzyme that in humans is encoded by the CTDSP2 gene.
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Products for CTDSP2 gene
Catalog | Product Name | Application | Company |
GFS:E06170 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; ELISA kit | ELISA | n/a |
GFS:A06170 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; Anti | ANTIBODIES | n/a |
GFS:P06170 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; Protien | Protien | n/a |