Symbol: Name: ID: |
COPS7B COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) GFS:5846 |
Gene name: | COPS7B |
Chromosome: | 2q37.1 |
Previous Symbols: | |
Previous Names: | COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 7B |
Aliases: | CSN7B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1349388 | Rat Genome Database ID: | RGD:1306918 |
HGNC ID: | HGNC:16760 | RefSeq IDs: | NM_022730 |
Entrez Gene ID: | 64708 | Ensembl Gene ID: | ENSG00000144524 |
VEGA IDs: | OTTHUMG00000133228 | UniProt ID: | Q9H9Q2 |
UCSC ID: | uc002vsg.1 | OMIM ID: | |
Pubmed: | PMID9707402 | ||
CCDS IDs: | CCDSCCDS2488.1 |
COP9 signalosome complex subunit 7b is a protein that in humans is encoded by the COPS7B gene.
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Products for COPS7B gene
Catalog | Product Name | Application | Company |
GFS:E05846 | COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis); ELISA kit | ELISA | n/a |
GFS:A05846 | COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis); Anti | ANTIBODIES | n/a |
GFS:P05846 | COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis); Protien | Protien | n/a |