Symbol: Name: ID: |
COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) GFS:5799 |
Gene name: | COPS4 |
Chromosome: | 4q21.22 |
Previous Symbols: | |
Previous Names: | COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 4 |
Aliases: | CSN4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1349414 | Rat Genome Database ID: | RGD:1302952 |
HGNC ID: | HGNC:16702 | RefSeq IDs: | NM_016129 |
Entrez Gene ID: | 51138 | Ensembl Gene ID: | ENSG00000138663 |
VEGA IDs: | OTTHUMG00000130298 | UniProt ID: | Q9BT78 |
UCSC ID: | uc003hoa.2 | OMIM ID: | |
Pubmed: | PMID9707402 | ||
CCDS IDs: | CCDSCCDS3600.1 |
COP9 signalosome complex subunit 4 is a protein that in humans is encoded by the COPS4 gene.
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Products for COPS4 gene
Catalog | Product Name | Application | Company |
GFS:E05799 | COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis); ELISA kit | ELISA | n/a |
GFS:A05799 | COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis); Anti | ANTIBODIES | n/a |
GFS:P05799 | COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis); Protien | Protien | n/a |