| Symbol: Name: ID: |
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase GFS:6755 |
| Gene name: | IBTK |
| Chromosome: | 6q14.3 |
| Previous Symbols: | BTKI |
| Previous Names: | Bruton agammaglobulinemia tyrosine kinase inhibitor |
| Aliases: | DKFZP564B116 |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1918677 | Rat Genome Database ID: | |
| HGNC ID: | HGNC:17853 | RefSeq IDs: | NM_015525 |
| Entrez Gene ID: | 25998 | Ensembl Gene ID: | ENSG00000005700 |
| VEGA IDs: | OTTHUMG00000015102 | UniProt ID: | Q9P2D0 |
| UCSC ID: | uc003pjl.1 | OMIM ID: | 606457 |
| Pubmed: | PMID11577348 | ||
| CCDS IDs: | CCDSCCDS34490.1 | ||
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. [provided by RefSeq, Jul 2008].
Function: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
Products for IBTK gene
| Catalog | Product Name | Application | Company |
| GFS:E06755 | inhibitor of Bruton agammaglobulinemia tyrosine kinase; ELISA kit | ELISA | n/a |
| GFS:A06755 | inhibitor of Bruton agammaglobulinemia tyrosine kinase; Anti | ANTIBODIES | n/a |
| GFS:P06755 | inhibitor of Bruton agammaglobulinemia tyrosine kinase; Protien | Protien | n/a |
