Symbol: Name: ID: |
ZYX zyxin GFS:2861 |
Gene name: | ZYX |
Chromosome: | 7q32 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103072 | Rat Genome Database ID: | RGD:620698 |
HGNC ID: | HGNC:13200 | RefSeq IDs: | NM_001010972 |
Entrez Gene ID: | 7791 | Ensembl Gene ID: | ENSG00000159840 |
VEGA IDs: | OTTHUMG00000023822 | UniProt ID: | Q15942 |
UCSC ID: | uc003wcx.2 | OMIM ID: | 602002 |
Pubmed: | PMID8917469 PMID 8940160 | ||
CCDS IDs: | CCDSCCDS5883.1 |
Zyxin is a protein that in humans is encoded by the ZYX gene.
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq].
Function: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).
Products for ZYX gene
Catalog | Product Name | Application | Company |
GFS:E02861 | zyxin; ELISA kit | ELISA | n/a |
GFS:A02861 | zyxin; Anti | ANTIBODIES | n/a |
GFS:P02861 | zyxin; Protien | Protien | n/a |