Symbol: Name: ID: |
ZP4 zona pellucida glycoprotein 4 GFS:4920 |
Gene name: | ZP4 |
Chromosome: | 1q43 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ZPB |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3690088 | Rat Genome Database ID: | |
HGNC ID: | HGNC:15770 | RefSeq IDs: | NM_021186 |
Entrez Gene ID: | 57829 | Ensembl Gene ID: | ENSG00000116996 |
VEGA IDs: | OTTHUMG00000039586 | UniProt ID: | Q12836 |
UCSC ID: | uc001hym.2 | OMIM ID: | 613514 |
Pubmed: | PMID7841460 | ||
CCDS IDs: | CCDSCCDS1615.1 |
Zona pellucida sperm-binding protein 4 is a protein that in humans is encoded by the ZP4 gene.
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
Products for ZP4 gene
Catalog | Product Name | Application | Company |
GFS:E04920 | zona pellucida glycoprotein 4; ELISA kit | ELISA | n/a |
GFS:A04920 | zona pellucida glycoprotein 4; Anti | ANTIBODIES | n/a |
GFS:P04920 | zona pellucida glycoprotein 4; Protien | Protien | n/a |