Symbol: Name: ID: |
ZNF423 zinc finger protein 423 GFS:5848 |
Gene name: | ZNF423 |
Chromosome: | 16q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0760, OAZ, Roaz, Ebfaz, Zfp104 |
Name Aliases: | OLF-1/EBF associated zinc finger gene, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891217 | Rat Genome Database ID: | RGD:621664 |
HGNC ID: | HGNC:16762 | RefSeq IDs: | NM_015069 |
Entrez Gene ID: | 23090 | Ensembl Gene ID: | ENSG00000102935 |
VEGA IDs: | UniProt ID: | Q2M1K9 | |
UCSC ID: | uc002efs.2 | OMIM ID: | 604557 |
Pubmed: | PMID9872452 PMID 10660046 | ||
CCDS IDs: | CCDSCCDS32445.1 |
Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene.
The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
Products for ZNF423 gene
Catalog | Product Name | Application | Company |
GFS:E05848 | zinc finger protein 423; ELISA kit | ELISA | n/a |
GFS:A05848 | zinc finger protein 423; Anti | ANTIBODIES | n/a |
GFS:P05848 | zinc finger protein 423; Protien | Protien | n/a |