Symbol: Name: ID: |
ZEB1 zinc finger E-box binding homeobox 1 GFS:1488 |
Gene name: | ZEB1 |
Chromosome: | 10p11.22 |
Previous Symbols: | TCF8 |
Previous Names: | transcription factor 8 (represses interleukin 2 expression) |
Aliases: | BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344313 | Rat Genome Database ID: | RGD:3831 |
HGNC ID: | HGNC:11642 | RefSeq IDs: | NM_001128128 |
Entrez Gene ID: | 6935 | Ensembl Gene ID: | ENSG00000148516 |
VEGA IDs: | OTTHUMG00000017907 | UniProt ID: | P37275 |
UCSC ID: | uc001ivs.3 | OMIM ID: | 189909 |
Pubmed: | PMID1427828 PMID 1840704 | ||
CCDS IDs: | CCDSCCDS7169.1 CCDS CCDS44370.1 |
Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene. This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.
Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Products for ZEB1 gene
Catalog | Product Name | Application | Company |
GFS:E01488 | zinc finger E-box binding homeobox 1; ELISA kit | ELISA | n/a |
GFS:A01488 | zinc finger E-box binding homeobox 1; Anti | ANTIBODIES | n/a |
GFS:P01488 | zinc finger E-box binding homeobox 1; Protien | Protien | n/a |