Symbol: Name: ID: |
ZNRF1 zinc and ring finger 1 GFS:7302 |
Gene name: | ZNRF1 |
Chromosome: | 16q22.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | nin283, FLJ14846, DKFZp434E229 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2177308 | Rat Genome Database ID: | |
HGNC ID: | HGNC:18452 | RefSeq IDs: | NM_032268 |
Entrez Gene ID: | 84937 | Ensembl Gene ID: | ENSG00000186187 |
VEGA IDs: | OTTHUMG00000137606 | UniProt ID: | Q8ND25 |
UCSC ID: | uc002fdl.1 | OMIM ID: | 612060 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS10912.1 |
E3 ubiquitin-protein ligase ZNRF1 is an enzyme that in humans is encoded by the ZNRF1 gene.
In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to substrates. May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin-protein ligase activity.
Products for ZNRF1 gene
Catalog | Product Name | Application | Company |
GFS:E07302 | zinc and ring finger 1; ELISA kit | ELISA | n/a |
GFS:A07302 | zinc and ring finger 1; Anti | ANTIBODIES | n/a |
GFS:P07302 | zinc and ring finger 1; Protien | Protien | n/a |