Symbol: Name: ID: |
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa GFS:2605 |
Gene name: | ZAP70 |
Chromosome: | 2q11-q13 |
Previous Symbols: | SRK |
Previous Names: | zeta-chain (TCR) associated protein kinase (70 kD) |
Aliases: | ZAP-70, STD |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99613 | Rat Genome Database ID: | RGD:3983 |
HGNC ID: | HGNC:12858 | RefSeq IDs: | NM_001079 |
Entrez Gene ID: | 7535 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000153060 | UniProt ID: | P43403 |
UCSC ID: | uc002syd.1 | OMIM ID: | 176947 |
Pubmed: | PMID1423621 | ||
CCDS IDs: | CCDSCCDS33254.1 CCDS CCDS33255.1 |
ZAP-70 is an abbreviation for Zeta-chain-associated protein kinase 70 (70 is the molecular weight in kDa). The protein is a member in the protein-tyrosine kinase family. ZAP-70 is normally expressed in T cells and natural killer cells and has a critical role in the initiation of T-cell signaling.
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq].
Function: Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.
Products for ZAP70 gene
Catalog | Product Name | Application | Company |
GFS:E02605 | zeta-chain (TCR) associated protein kinase 70kDa; ELISA kit | ELISA | n/a |
GFS:A02605 | zeta-chain (TCR) associated protein kinase 70kDa; Anti | ANTIBODIES | n/a |
GFS:P02605 | zeta-chain (TCR) associated protein kinase 70kDa; Protien | Protien | n/a |