Symbol: Name: ID: |
XPA xeroderma pigmentosum, complementation group A GFS:2570 |
Gene name: | XPA |
Chromosome: | 9q22.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | XPAC, XP1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99135 | Rat Genome Database ID: | RGD:1308769 |
HGNC ID: | HGNC:12814 | RefSeq IDs: | NM_000380 |
Entrez Gene ID: | 7507 | Ensembl Gene ID: | ENSG00000136936 |
VEGA IDs: | OTTHUMG00000020330 | UniProt ID: | P23025 |
UCSC ID: | uc004axr.3 | OMIM ID: | 611153 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS6729.1 |
DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene.
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
Function: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Products for XPA gene
Catalog | Product Name | Application | Company |
GFS:E02570 | xeroderma pigmentosum, complementation group A; ELISA kit | ELISA | n/a |
GFS:A02570 | xeroderma pigmentosum, complementation group A; Anti | ANTIBODIES | n/a |
GFS:P02570 | xeroderma pigmentosum, complementation group A; Protien | Protien | n/a |