Symbol: Name: ID: |
VWF von Willebrand factor GFS:2495 |
Gene name: | VWF |
Chromosome: | 12p13.3 |
Previous Symbols: | F8VWF |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98941 | Rat Genome Database ID: | RGD:621759 |
HGNC ID: | HGNC:12726 | RefSeq IDs: | NM_000552 |
Entrez Gene ID: | 7450 | Ensembl Gene ID: | ENSG00000110799 |
VEGA IDs: | UniProt ID: | P04275 | |
UCSC ID: | uc001qnn.1 | OMIM ID: | 613160 |
Pubmed: | PMID2251280 | ||
CCDS IDs: | CCDSCCDS8539.1 |
Von Willebrand factor (vWF) is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome. Increased plasma levels in a large numbers of cardiovascular, neoplastic and connective tissue diseases are presumed to arise from adverse changes to the endothelium, and seem likely to contribute to an increased risk of thrombosis.
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for VWF gene
Catalog | Product Name | Application | Company |
GFS:E02495 | von Willebrand factor; ELISA kit | ELISA | n/a |
GFS:A02495 | von Willebrand factor; Anti | ANTIBODIES | n/a |
GFS:P02495 | von Willebrand factor; Protien | Protien | n/a |