Symbol: Name: ID: |
VDAC2 voltage-dependent anion channel 2 GFS:2452 |
Gene name: | VDAC2 |
Chromosome: | 10q22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:106915 | Rat Genome Database ID: | RGD:621576 |
HGNC ID: | HGNC:12672 | RefSeq IDs: | NM_001184783 |
Entrez Gene ID: | 7417 | Ensembl Gene ID: | ENSG00000165637 |
VEGA IDs: | OTTHUMG00000018517 | UniProt ID: | P45880 |
UCSC ID: | uc001jwz.2 | OMIM ID: | 193245 |
Pubmed: | PMID7517385 PMID 10049775 | ||
CCDS IDs: | CCDSCCDS7348.1 |
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq].
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
Products for VDAC2 gene
Catalog | Product Name | Application | Company |
GFS:E02452 | voltage-dependent anion channel 2; ELISA kit | ELISA | n/a |
GFS:A02452 | voltage-dependent anion channel 2; Anti | ANTIBODIES | n/a |
GFS:P02452 | voltage-dependent anion channel 2; Protien | Protien | n/a |