Symbol: Name: ID: |
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor GFS:2458 |
Gene name: | VDR |
Chromosome: | 12q12-q14 |
Previous Symbols: | |
Previous Names: | |
Aliases: | NR1I1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103076 | Rat Genome Database ID: | RGD:3959 |
HGNC ID: | HGNC:12679 | RefSeq IDs: | NM_000376 |
Entrez Gene ID: | 7421 | Ensembl Gene ID: | ENSG00000111424 |
VEGA IDs: | UniProt ID: | P11473 | |
UCSC ID: | uc001rqn.2 | OMIM ID: | 601769 |
Pubmed: | PMID1662663 | ||
CCDS IDs: | CCDSCCDS8757.1 |
The calcitriol receptor, also known as the vitamin D receptor (VDR) and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors.[1] Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or transrepression of specific geneproducts. In humans, the vitamin D receptor is encoded by the VDR gene.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq].
Products for VDR gene
Catalog | Product Name | Application | Company |
GFS:E02458 | vitamin D (1,25- dihydroxyvitamin D3) receptor; ELISA kit | ELISA | n/a |
GFS:A02458 | vitamin D (1,25- dihydroxyvitamin D3) receptor; Anti | ANTIBODIES | n/a |
GFS:P02458 | vitamin D (1,25- dihydroxyvitamin D3) receptor; Protien | Protien | n/a |