Symbol: Name: ID: |
VCL vinculin GFS:2445 |
Gene name: | VCL |
Chromosome: | 10q22.1-q23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | metavinculin |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98927 | Rat Genome Database ID: | RGD:1311217 |
HGNC ID: | HGNC:12665 | RefSeq IDs: | NM_003373 |
Entrez Gene ID: | 7414 | Ensembl Gene ID: | ENSG00000035403 |
VEGA IDs: | OTTHUMG00000018498 | UniProt ID: | P18206 |
UCSC ID: | uc001jwd.2 | OMIM ID: | 193065 |
Pubmed: | PMID1339348 | ||
CCDS IDs: | CCDSCCDS7340.1 CCDS CCDS7341.1 |
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq].
Function: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Products for VCL gene
Catalog | Product Name | Application | Company |
GFS:E02445 | vinculin; ELISA kit | ELISA | n/a |
GFS:A02445 | vinculin; Anti | ANTIBODIES | n/a |
GFS:P02445 | vinculin; Protien | Protien | n/a |