Symbol: Name: ID: |
VIM vimentin GFS:2467 |
Gene name: | VIM |
Chromosome: | 10p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98932 | Rat Genome Database ID: | RGD:621646 |
HGNC ID: | HGNC:12692 | RefSeq IDs: | NM_003380 |
Entrez Gene ID: | 7431 | Ensembl Gene ID: | ENSG00000026025 |
VEGA IDs: | OTTHUMG00000017744 | UniProt ID: | P08670 |
UCSC ID: | uc001iou.2 | OMIM ID: | 193060 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS7120.1 |
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. IF proteins are found in all metazoan cells[1] as well as bacteria.[2] IF, along with tubulin-based microtubules and actin-based microfilaments, comprise the cytoskeleton. All IF proteins are expressed in a highly developmentally-regulated fashion; vimentin is the major cytoskeletal component of mesenchymal cells. Because of this, vimentin is often used as a marker of mesenchymally-derived cells or cells undergoing an epithelial-to-mesenchymal transition (EMT) during both normal development and metastatic progression.
Products for VIM gene
Catalog | Product Name | Application | Company |
GFS:E02467 | vimentin; ELISA kit | ELISA | n/a |
GFS:A02467 | vimentin; Anti | ANTIBODIES | n/a |
GFS:P02467 | vimentin; Protien | Protien | n/a |