Symbol: Name: ID: |
VLDLR very low density lipoprotein receptor GFS:2473 |
Gene name: | VLDLR |
Chromosome: | 9p24 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98935 | Rat Genome Database ID: | RGD:3963 |
HGNC ID: | HGNC:12698 | RefSeq IDs: | NM_001018056 |
Entrez Gene ID: | 7436 | Ensembl Gene ID: | ENSG00000147852 |
VEGA IDs: | OTTHUMG00000019447 | UniProt ID: | P98155 |
UCSC ID: | uc003zhk.1 | OMIM ID: | 192977 |
Pubmed: | PMID8294473 | ||
CCDS IDs: | CCDSCCDS6446.1 CCDS CCDS34979.1 |
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq].
Function: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
Products for VLDLR gene
Catalog | Product Name | Application | Company |
GFS:E02473 | very low density lipoprotein receptor; ELISA kit | ELISA | n/a |
GFS:A02473 | very low density lipoprotein receptor; Anti | ANTIBODIES | n/a |
GFS:P02473 | very low density lipoprotein receptor; Protien | Protien | n/a |