Symbol: Name: ID: |
VEGFC vascular endothelial growth factor C GFS:2462 |
Gene name: | VEGFC |
Chromosome: | 4q34.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | VRP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109124 | Rat Genome Database ID: | RGD:619800 |
HGNC ID: | HGNC:12682 | RefSeq IDs: | NM_005429 |
Entrez Gene ID: | 7424 | Ensembl Gene ID: | ENSG00000150630 |
VEGA IDs: | UniProt ID: | P49767 | |
UCSC ID: | uc003ius.1 | OMIM ID: | 601528 |
Pubmed: | PMID8617204 | ||
CCDS IDs: |
Vascular endothelial growth factor C is a VEGF. The human gene encoding it is VEGFC.
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Products for VEGFC gene
Catalog | Product Name | Application | Company |
GFS:E02462 | vascular endothelial growth factor C; ELISA kit | ELISA | n/a |
GFS:A02462 | vascular endothelial growth factor C; Anti | ANTIBODIES | n/a |
GFS:P02462 | vascular endothelial growth factor C; Protien | Protien | n/a |