Symbol: Name: ID: |
VEGFA vascular endothelial growth factor A GFS:2460 |
Gene name: | VEGFA |
Chromosome: | 6p12 |
Previous Symbols: | VEGF |
Previous Names: | vascular endothelial growth factor |
Aliases: | VEGF-A, VPF |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103178 | Rat Genome Database ID: | RGD:619991 |
HGNC ID: | HGNC:12680 | RefSeq IDs: | NM_001025366 |
Entrez Gene ID: | 7422 | Ensembl Gene ID: | ENSG00000112715 |
VEGA IDs: | OTTHUMG00000014745 | UniProt ID: | P15692 |
UCSC ID: | uc003owh.2 | OMIM ID: | 192240 |
Pubmed: | PMID8786112 | ||
CCDS IDs: | CCDSCCDS34457.1 CCDS CCDS4907.2 CCDS CCDS34458.1 CCDS CCDS47432.1 CCDS CCDS47433.1 CCDS CCDS47434.1 CCDS CCDS47435.1 |
Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene.
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq].
Products for VEGFA gene
Catalog | Product Name | Application | Company |
GFS:E02460 | vascular endothelial growth factor A; ELISA kit | ELISA | n/a |
GFS:A02460 | vascular endothelial growth factor A; Anti | ANTIBODIES | n/a |
GFS:P02460 | vascular endothelial growth factor A; Protien | Protien | n/a |