Symbol: Name: ID: |
VCAM1 vascular cell adhesion molecule 1 GFS:2443 |
Gene name: | VCAM1 |
Chromosome: | 1p32-p31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CD106 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98926 | Rat Genome Database ID: | RGD:3952 |
HGNC ID: | HGNC:12663 | RefSeq IDs: | NM_001078 |
Entrez Gene ID: | 7412 | Ensembl Gene ID: | ENSG00000162692 |
VEGA IDs: | OTTHUMG00000010982 | UniProt ID: | P19320 |
UCSC ID: | uc001dti.2 | OMIM ID: | 192225 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS773.1 CCDS CCDS774.1 |
Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene.
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq].
Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Products for VCAM1 gene
Catalog | Product Name | Application | Company |
GFS:E02443 | vascular cell adhesion molecule 1; ELISA kit | ELISA | n/a |
GFS:A02443 | vascular cell adhesion molecule 1; Anti | ANTIBODIES | n/a |
GFS:P02443 | vascular cell adhesion molecule 1; Protien | Protien | n/a |