Symbol: Name: ID: |
VRK1 vaccinia related kinase 1 GFS:2486 |
Gene name: | VRK1 |
Chromosome: | 14q32 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1261847 | Rat Genome Database ID: | RGD:1306069 |
HGNC ID: | HGNC:12718 | RefSeq IDs: | NM_003384 |
Entrez Gene ID: | 7443 | Ensembl Gene ID: | ENSG00000100749 |
VEGA IDs: | UniProt ID: | Q99986 | |
UCSC ID: | uc001yft.2 | OMIM ID: | 602168 |
Pubmed: | PMID9344656 | ||
CCDS IDs: | CCDSCCDS9947.1 |
Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Serine/threonine kinase that phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2.
Products for VRK1 gene
Catalog | Product Name | Application | Company |
GFS:E02486 | vaccinia related kinase 1; ELISA kit | ELISA | n/a |
GFS:A02486 | vaccinia related kinase 1; Anti | ANTIBODIES | n/a |
GFS:P02486 | vaccinia related kinase 1; Protien | Protien | n/a |