Symbol: Name: ID: |
BRAF v-raf murine sarcoma viral oncogene homolog B1 GFS:876 |
Gene name: | BRAF |
Chromosome: | 7q34 |
Previous Symbols: | |
Previous Names: | |
Aliases: | BRAF1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88190 | Rat Genome Database ID: | RGD:619908 |
HGNC ID: | HGNC:1097 | RefSeq IDs: | NM_004333 |
Entrez Gene ID: | 673 | Ensembl Gene ID: | ENSG00000157764 |
VEGA IDs: | OTTHUMG00000157457 | UniProt ID: | P15056 |
UCSC ID: | uc003vwc.3 | OMIM ID: | 164757 |
Pubmed: | PMID2284096 PMID 1565476 | ||
CCDS IDs: | CCDSCCDS5863.1 |
Serine/threonine-protein kinase B-Raf or simply B-Raf, also known as proto-oncogene B-Raf or v-Raf murine sarcoma viral oncogene homolog B1, is a protein that in humans is encoded by the BRAF gene. This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron.
Products for BRAF gene
Catalog | Product Name | Application | Company |
GFS:E00876 | v-raf murine sarcoma viral oncogene homolog B1; ELISA kit | ELISA | n/a |
GFS:A00876 | v-raf murine sarcoma viral oncogene homolog B1; Anti | ANTIBODIES | n/a |
GFS:P00876 | v-raf murine sarcoma viral oncogene homolog B1; Protien | Protien | n/a |