Symbol: Name: ID: |
UNG uracil-DNA glycosylase GFS:2358 |
Gene name: | UNG |
Chromosome: | 12q23-q24.1 |
Previous Symbols: | DGU |
Previous Names: | |
Aliases: | UDG, UNG1, UNG2, HIGM4 |
Name Aliases: | uracil-DNA glycosylase 1, uracil-DNA glycosylase 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109352 | Rat Genome Database ID: | RGD:1307200 |
HGNC ID: | HGNC:12572 | RefSeq IDs: | NM_003362 |
Entrez Gene ID: | 7374 | Ensembl Gene ID: | |
VEGA IDs: | UniProt ID: | P13051 | |
UCSC ID: | uc001tnz.1 | OMIM ID: | 191525 |
Pubmed: | PMID1923798 PMID 17101234 | ||
CCDS IDs: | CCDSCCDS9124.1 CCDS CCDS9125.1 |
Uracil-DNA glycosylase, also known as UNG or UDG, is a human gene though orthologs exist ubiquitously among prokaryotes and eukaryotes and even in some DNA viruses. The first uracil DNA-glycosylase was isolated from Escherichia coli. The human gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2.
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq].
Products for UNG gene
Catalog | Product Name | Application | Company |
GFS:E02358 | uracil-DNA glycosylase; ELISA kit | ELISA | n/a |
GFS:A02358 | uracil-DNA glycosylase; Anti | ANTIBODIES | n/a |
GFS:P02358 | uracil-DNA glycosylase; Protien | Protien | n/a |