Symbol: Name: ID: |
UBTF upstream binding transcription factor, RNA polymerase I GFS:2303 |
Gene name: | UBTF |
Chromosome: | 17q21.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | UBF, NOR-90 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98512 | Rat Genome Database ID: | RGD:3927 |
HGNC ID: | HGNC:12511 | RefSeq IDs: | NM_001076683 |
Entrez Gene ID: | 7343 | Ensembl Gene ID: | ENSG00000108312 |
VEGA IDs: | UniProt ID: | P17480 | |
UCSC ID: | uc002igb.2 | OMIM ID: | 600673 |
Pubmed: | PMID9126496 | ||
CCDS IDs: | CCDSCCDS11480.1 CCDS CCDS42346.1 |
Nucleolar transcription factor 1 is a protein that in humans is encoded by the UBTF gene.
Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990 [PubMed 2330041]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
Products for UBTF gene
Catalog | Product Name | Application | Company |
GFS:E02303 | upstream binding transcription factor, RNA polymerase I; ELISA kit | ELISA | n/a |
GFS:A02303 | upstream binding transcription factor, RNA polymerase I; Anti | ANTIBODIES | n/a |
GFS:P02303 | upstream binding transcription factor, RNA polymerase I; Protien | Protien | n/a |