Symbol: Name: ID: |
UXT ubiquitously-expressed transcript GFS:2421 |
Gene name: | UXT |
Chromosome: | Xp11.23-p11.22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ART-27 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1277988 | Rat Genome Database ID: | RGD:1359326 |
HGNC ID: | HGNC:12641 | RefSeq IDs: | NM_004182 |
Entrez Gene ID: | 8409 | Ensembl Gene ID: | ENSG00000126756 |
VEGA IDs: | OTTHUMG00000021453 | UniProt ID: | Q9UBK9 |
UCSC ID: | uc004dim.2 | OMIM ID: | 300234 |
Pubmed: | PMID10087202 PMID 16221885 | ||
CCDS IDs: | CCDSCCDS14284.1 CCDS CCDS14285.1 |
Protein UXT (Ubiquitously eXpressed Transcript protein) also known as androgen receptor trapped clone 27 (ART-27) protein is a protein that in humans is encoded by the UXT gene.
This gene encodes a novel protein which is highly conserved in mouse. It interacts with the N-terminus of the androgen receptor and plays a role in facilitating receptor-induced transcriptional activation. It is also likely to be involved in tumorigenesis as it is abundantly expressed in tumor tissues. This gene is part of a gene cluster on chromosome Xp11.23. Alternative splicing results in 2 transcript variants encoding different isoforms. [provided by RefSeq].
Function: Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584).
Products for UXT gene
Catalog | Product Name | Application | Company |
GFS:E02421 | ubiquitously-expressed transcript; ELISA kit | ELISA | n/a |
GFS:A02421 | ubiquitously-expressed transcript; Anti | ANTIBODIES | n/a |
GFS:P02421 | ubiquitously-expressed transcript; Protien | Protien | n/a |