Symbol: Name: ID: |
UBR1 ubiquitin protein ligase E3 component n-recognin 1 GFS:5893 |
Gene name: | UBR1 |
Chromosome: | 15q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1277977 | Rat Genome Database ID: | RGD:1562326 |
HGNC ID: | HGNC:16808 | RefSeq IDs: | NM_174916 |
Entrez Gene ID: | 197131 | Ensembl Gene ID: | ENSG00000159459 |
VEGA IDs: | OTTHUMG00000130702 | UniProt ID: | Q8IWV7 |
UCSC ID: | uc001zqq.2 | OMIM ID: | 605981 |
Pubmed: | PMID9653112 | ||
CCDS IDs: | CCDSCCDS10091.1 |
The human gene UBR1 encodes the enzyme ubiquitin-protein ligase E3 component n-recognin 1.
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Products for UBR1 gene
Catalog | Product Name | Application | Company |
GFS:E05893 | ubiquitin protein ligase E3 component n-recognin 1; ELISA kit | ELISA | n/a |
GFS:A05893 | ubiquitin protein ligase E3 component n-recognin 1; Anti | ANTIBODIES | n/a |
GFS:P05893 | ubiquitin protein ligase E3 component n-recognin 1; Protien | Protien | n/a |