Symbol: Name: ID: |
UFD1L ubiquitin fusion degradation 1 like (yeast) GFS:2311 |
Gene name: | UFD1L |
Chromosome: | 22q11.2 |
Previous Symbols: | |
Previous Names: | ubiquitin fusion degradation 1-like |
Aliases: | UFD1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109353 | Rat Genome Database ID: | RGD:619822 |
HGNC ID: | HGNC:12520 | RefSeq IDs: | NM_001035247 |
Entrez Gene ID: | 7353 | Ensembl Gene ID: | ENSG00000070010 |
VEGA IDs: | OTTHUMG00000150130 | UniProt ID: | Q92890 |
UCSC ID: | uc002zpm.2 | OMIM ID: | 601754 |
Pubmed: | PMID9063746 | ||
CCDS IDs: | CCDSCCDS13761.1 CCDS CCDS33600.1 |
Ubiquitin fusion degradation protein 1 homolog is a protein that in humans is encoded by the UFD1L gene.
The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq].
Function: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
Products for UFD1L gene
Catalog | Product Name | Application | Company |
GFS:E02311 | ubiquitin fusion degradation 1 like (yeast); ELISA kit | ELISA | n/a |
GFS:A02311 | ubiquitin fusion degradation 1 like (yeast); Anti | ANTIBODIES | n/a |
GFS:P02311 | ubiquitin fusion degradation 1 like (yeast); Protien | Protien | n/a |