Symbol: Name: ID: |
UBQLN1 ubiquilin 1 GFS:2300 |
Gene name: | UBQLN1 |
Chromosome: | 9q22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | DSK2, PLIC-1, XDRP1, DA41 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1860276 | Rat Genome Database ID: | RGD:620745 |
HGNC ID: | HGNC:12508 | RefSeq IDs: | NM_013438 |
Entrez Gene ID: | 29979 | Ensembl Gene ID: | ENSG00000135018 |
VEGA IDs: | OTTHUMG00000020104 | UniProt ID: | Q9UMX0 |
UCSC ID: | uc004amv.2 | OMIM ID: | 605046 |
Pubmed: | PMID9303440 PMID 10807547 | ||
CCDS IDs: | CCDSCCDS6663.1 CCDS CCDS6664.1 |
Ubiquilin-1 is a protein that in humans is encoded by the UBQLN1 gene.
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Function: Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation.
Products for UBQLN1 gene
Catalog | Product Name | Application | Company |
GFS:E02300 | ubiquilin 1; ELISA kit | ELISA | n/a |
GFS:A02300 | ubiquilin 1; Anti | ANTIBODIES | n/a |
GFS:P02300 | ubiquilin 1; Protien | Protien | n/a |