Symbol: Name: ID: |
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide GFS:2598 |
Gene name: | YWHAE |
Chromosome: | 17p13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ45465 |
Name Aliases: | 14-3-3 epsilon |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:894689 | Rat Genome Database ID: | RGD:62000 |
HGNC ID: | HGNC:12851 | RefSeq IDs: | NM_006761 |
Entrez Gene ID: | 7531 | Ensembl Gene ID: | ENSG00000108953 |
VEGA IDs: | OTTHUMG00000134316 | UniProt ID: | P62258 |
UCSC ID: | uc002fsj.2 | OMIM ID: | 605066 |
Pubmed: | PMID9371399 | ||
CCDS IDs: | CCDSCCDS11001.1 |
14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq].
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Products for YWHAE gene
Catalog | Product Name | Application | Company |
GFS:E02598 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; ELISA kit | ELISA | n/a |
GFS:A02598 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Anti | ANTIBODIES | n/a |
GFS:P02598 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Protien | Protien | n/a |