Symbol: Name: ID: |
TULP3 tubby like protein 3 GFS:2227 |
Gene name: | TULP3 |
Chromosome: | 12p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TUBL3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1329045 | Rat Genome Database ID: | RGD:1585259 |
HGNC ID: | HGNC:12425 | RefSeq IDs: | NM_001160408 |
Entrez Gene ID: | 7289 | Ensembl Gene ID: | ENSG00000078246 |
VEGA IDs: | UniProt ID: | O75386 | |
UCSC ID: | uc001qlj.2 | OMIM ID: | 604730 |
Pubmed: | PMID9828123 | ||
CCDS IDs: | CCDSCCDS8519.1 |
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq].
Function: Negatively regulates SHH signal transduction (By similarity). Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids.
Products for TULP3 gene
Catalog | Product Name | Application | Company |
GFS:E02227 | tubby like protein 3; ELISA kit | ELISA | n/a |
GFS:A02227 | tubby like protein 3; Anti | ANTIBODIES | n/a |
GFS:P02227 | tubby like protein 3; Protien | Protien | n/a |