Symbol: Name: ID: |
WARS tryptophanyl-tRNA synthetase GFS:2497 |
Gene name: | WARS |
Chromosome: | 14q32.2 |
Previous Symbols: | IFI53 |
Previous Names: | |
Aliases: | IFP53 |
Name Aliases: | tryptophan tRNA ligase 1, cytoplasmic |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104630 | Rat Genome Database ID: | RGD:1308278 |
HGNC ID: | HGNC:12729 | RefSeq IDs: | NM_004184 |
Entrez Gene ID: | 7453 | Ensembl Gene ID: | ENSG00000140105 |
VEGA IDs: | UniProt ID: | P23381 | |
UCSC ID: | uc001yhl.1 | OMIM ID: | 191050 |
Pubmed: | PMID1537332 PMID 1763065 | ||
CCDS IDs: | CCDSCCDS9960.1 CCDS CCDS9961.1 |
Tryptophanyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the WARS gene.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq].
Function: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
Products for WARS gene
Catalog | Product Name | Application | Company |
GFS:E02497 | tryptophanyl-tRNA synthetase; ELISA kit | ELISA | n/a |
GFS:A02497 | tryptophanyl-tRNA synthetase; Anti | ANTIBODIES | n/a |
GFS:P02497 | tryptophanyl-tRNA synthetase; Protien | Protien | n/a |