Symbol: Name: ID: |
TNNT3 troponin T type 3 (skeletal, fast) GFS:1761 |
Gene name: | TNNT3 |
Chromosome: | 11p15.5 |
Previous Symbols: | |
Previous Names: | troponin T3, skeletal, fast |
Aliases: | AMCD2B, DA2B, FSSV, DKFZp779M2348 |
Name Aliases: | troponin-T3, skeletal, fast |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109550 | Rat Genome Database ID: | RGD:3883 |
HGNC ID: | HGNC:11950 | RefSeq IDs: | NM_001042780 |
Entrez Gene ID: | 7140 | Ensembl Gene ID: | ENSG00000130595 |
VEGA IDs: | OTTHUMG00000012475 | UniProt ID: | P45378 |
UCSC ID: | uc001luu.3 | OMIM ID: | 600692 |
Pubmed: | PMID8172653 | ||
CCDS IDs: | CCDSCCDS7727.1 CCDS CCDS41594.1 CCDS CCDS41595.1 CCDS CCDS41596.1 |
Troponin T, fast skeletal muscle is a protein that in humans is encoded by the TNNT3 gene. The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq].
Products for TNNT3 gene
Catalog | Product Name | Application | Company |
GFS:E01761 | troponin T type 3 (skeletal, fast); ELISA kit | ELISA | n/a |
GFS:A01761 | troponin T type 3 (skeletal, fast); Anti | ANTIBODIES | n/a |
GFS:P01761 | troponin T type 3 (skeletal, fast); Protien | Protien | n/a |