Symbol: Name: ID: |
TPM4 tropomyosin 4 GFS:1813 |
Gene name: | TPM4 |
Chromosome: | 19p13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2449202 | Rat Genome Database ID: | RGD:3899 |
HGNC ID: | HGNC:12013 | RefSeq IDs: | NM_001145160 |
Entrez Gene ID: | 7171 | Ensembl Gene ID: | ENSG00000167460 |
VEGA IDs: | UniProt ID: | P67936 | |
UCSC ID: | uc002ndi.2 | OMIM ID: | 600317 |
Pubmed: | PMID8641132 | ||
CCDS IDs: | CCDSCCDS12338.1 CCDS CCDS46007.1 |
Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene. This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
Products for TPM4 gene
Catalog | Product Name | Application | Company |
GFS:E01813 | tropomyosin 4; ELISA kit | ELISA | n/a |
GFS:A01813 | tropomyosin 4; Anti | ANTIBODIES | n/a |
GFS:P01813 | tropomyosin 4; Protien | Protien | n/a |