Symbol: Name: ID: |
TPP2 tripeptidyl peptidase II GFS:1816 |
Gene name: | TPP2 |
Chromosome: | 13q32-q33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:102724 | Rat Genome Database ID: | RGD:621584 |
HGNC ID: | HGNC:12016 | RefSeq IDs: | NM_003291 |
Entrez Gene ID: | 7174 | Ensembl Gene ID: | ENSG00000134900 |
VEGA IDs: | OTTHUMG00000017305 | UniProt ID: | P29144 |
UCSC ID: | uc001vpi.3 | OMIM ID: | 190470 |
Pubmed: | PMID1670990 | ||
CCDS IDs: | CCDSCCDS9502.1 |
Tripeptidyl-peptidase 2 is an enzyme that in humans is encoded by the TPP2 gene. This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity).
Products for TPP2 gene
Catalog | Product Name | Application | Company |
GFS:E01816 | tripeptidyl peptidase II; ELISA kit | ELISA | n/a |
GFS:A01816 | tripeptidyl peptidase II; Anti | ANTIBODIES | n/a |
GFS:P01816 | tripeptidyl peptidase II; Protien | Protien | n/a |