Symbol: Name: ID: |
TGS1 trimethylguanosine synthase 1 GFS:6744 |
Gene name: | TGS1 |
Chromosome: | 8q11 |
Previous Symbols: | NCOA6IP |
Previous Names: | nuclear receptor coactivator 6 interacting protein, "trimethylguanosine synthase homolog (S. cerevisiae)" |
Aliases: | PIMT |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2151797 | Rat Genome Database ID: | |
HGNC ID: | HGNC:17843 | RefSeq IDs: | NM_024831 |
Entrez Gene ID: | 96764 | Ensembl Gene ID: | ENSG00000137574 |
VEGA IDs: | UniProt ID: | Q96RS0 | |
UCSC ID: | uc003xsj.3 | OMIM ID: | 606461 |
Pubmed: | PMID11517327 PMID 11983179 PMID 19307714 | ||
CCDS IDs: | CCDSCCDS34894.1 |
Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.
Function: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Products for TGS1 gene
Catalog | Product Name | Application | Company |
GFS:E06744 | trimethylguanosine synthase 1; ELISA kit | ELISA | n/a |
GFS:A06744 | trimethylguanosine synthase 1; Anti | ANTIBODIES | n/a |
GFS:P06744 | trimethylguanosine synthase 1; Protien | Protien | n/a |